Y-boxīinding protein-1 (YB-1) is a multifunctional protein that regulates the cancer hallmarks among them resisting to In many patients, most likely because of DNA damage response (DDR) signaling mediated radioresistance. However, response to radiotherapy is limited Surgery, radiotherapy serves as the major treatment modality for TNBC. Our data therefore suggest that micro-structured surfaces with anisotropic topographies may improve long-term endothelialization of CVIs.īackground: Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. After cultivation on gridded surfaces, the cells showed significant improvements in terms of adherens junction integrity, cell elongation, and orientation of the actin filaments, as well as enhanced yes-associated protein nuclear translocation and cell proliferation. Considering that micro-structured surfaces with anisotropic topography may promote endothelialization, we investigated the impact of gratings on the biomechanical properties and the replicative capacity of senescent ECs. Consequently, extensive cell expansion is necessary, which may eventually lead to replicative senescence. Complete surficial coverage of CVIs by a monolayer of endothelial cells (ECs) prior to implantation represents a promising strategy but is hampered by the overall logistical complexity and the high number of cells required. Thrombogenicity remains a major issue in cardiovascular implants (CVIs).
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |